Which Dosage Form Is A Semisolid Oil-In-Water Emulsion Treating Petrowiki, High-Performance Marketing: An Interview With Nike’s Phil Knight

A variety of film-coating polymers are available and enable the development of specialized release profiles. The use of an occlusive dressing with the tape enhances the rate and extent of delivery of the drug substance to deeper layers of the skin and may result in greater systemic absorption of the drug substance. Foam: A dosage form containing gas bubbles dispersed in a liquid.

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Which Dosage Form Is A Semisolid Oil-In-Water Emulsion Drink

The term excipient is synonymous with inactive ingredient. Suspension: A liquid dosage form that consists of solid particles dispersed throughout a liquid phase. Frequently, thixotropic vehicles are used to counter particle-settling tendencies, but these vehicles must not interfere with pouring or redispersal. Semi-solid dosage (SSD) forms are a type of medication that is neither solid nor liquid; they are somewhere in between the two states. Coatings are applied for functional or aesthetic purposes such as taste masking, stability, modifying release characteristics, product identification, and appearance. Buccal films and sublingual films are formulated to facilitate absorption through the proximal mucosal membranes avoiding first pass metabolism or degradation in the gastrointestinal tract and providing a quick onset of action. Which dosage form is a semisolid oil-in-water emulsion paint. Oil-in-water emulsion |. All emulsions for oral administration are liquids, but emulsions for topical administration may be either liquid or semisolid. The ICH guideline on specifications, Q6A, notes that specifications are chosen to confirm the quality of the drug substance and drug product and defines quality as The suitability of either a drug substance or drug product for its intended use. Emollient, protective, non-greasy and easily removable. For general considerations, see 795. Examples include mineral oil, isoflurane, and ether. To clearly identify/distinguish preferred from not preferred terms, entries indicate when a term is not preferred and generally direct the user to the current preferred term.

Which Dosage Form Is A Semisolid Oil-In-Water Emulsion Water

Attribute of a material characterized by a reduced ability to flow or conform to its container at room temperature. Water washable and water soluble bases. Which dosage form is a semisolid oil-in-water emulsion water. Emulsifiers if allergy to these agents is a concern. When water is dispersed in oil, the emulsion is referred to as a water in oil (W/O) emulsion. Extended-release injectable suspension: Liquid preparations of solids suspended in a suitable vehicle and formulated to allow the drug substance to be available over an extended period of time.

Which Dosage Form Is A Semisolid Oil-In-Water Emulsion 5 Point Comparative

The procedure to assure sterility should be validated by media fills. Definition of semi-solid dosage form: Semisolid dosage forms are the topical dosage form used for the therapeutic, protective or cosmetic functions. This property is useful when one. They are more correctly categorized as gels (see Gels).

Which Dosage Form Is A Semisolid Oil-In-Water Emulsion Paint

You know this has occurred when the system changes from a translucent, oily-appearing liquid into a thick, white liquid. Aggregation is generally accompanied by a relatively rapid separation of an emulsion into a droplet-rich and droplet-poor phase. Uniformity of dosage units: See the discussion of Dose uniformity in the General Considerations section. Lotions are suitable for hairy areas, skin prone to folliculitis/acne, intertriginous. Can be considered a lotion. Lo·tion [ loh-shuhn]. Suspension dosage forms may be formulated for specific routes of administration such as oral, topical, inhalation, ophthalmic, otic, and injection. Dis: Greasy, difficult to spread |. Which dosage form is a semisolid oil-in-water emulsion. Effervescent: Attribute of an oral dosage form, frequently tablets or granules, containing ingredients that, when in contact with water, rapidly release carbon dioxide. Polymer implants can also be made by injection molding. One-piece or soft-shell capsules: One-piece capsules typically are used to deliver a drug substance as a solution or suspension. Antioxidants used in semisolid dosage form: Example: Butylated hydroxyanisole, Butylated hydroxytoluene. The blend is then processed through a conventional tablet press and tableted into desired shapes. Molded lozenges using a sucrose or sorbitol base containing drug substances such as phenol, dextromethorphan, fentanyl, and dyclonine hydrochloride and menthol are prepared by cooking the sugar (sucrose, corn syrup, and sorbitol) and water at about 150 to reduce the water content to less than 2%.

Which Dosage Form Is A Semisolid Oil-In-Water Emulsion

Even the glue used to affix the label to plastic packaging has the potential to migrate and compromise the medication. The design of the delivery system releases one dose with each actuation. Example durations of drug substance release are 2 and 3 months for biodegradable implants and up to 3 years for nonbiodegradable implants. Premix (not preferred; see Type A Medicated Articles and Type B Medicated Articles in Animal Drugs for Use in Animal Feeds 1152).

Which Dosage Form Is A Semisolid Oil-In-Water Emulsion 180Ml 21Ad

Allow the excess calcium hydroxide to settle. Suspensions are generally not injected intravenously, epidurally, or intrathecally unless the product labeling clearly specifies these routes of administration. External preparations are generally stored at controlled room temperature. A suspension is a biphasic preparation consisting of solid particles dispersed throughout a liquid phase. Granules are solid dosage forms that are composed of agglomerations of smaller particles. Dissolution: A test to measure the release of the drug substance(s) from the drug product normally is included for dosage forms such as tablets, capsules, suspensions, granules for suspensions, implants, transdermal delivery systems, and medicated chewing gums. Granules manufactured for this purpose are packaged in quantities sufficient for a limited time periodusually one course of therapy that typically does not exceed 2 weeks. As was discussed in Chapter 27, in 2002, USP formed a group to clarify pharmaceutical dosage form nomenclature. Typically, drug substances are dissolved or suspended in a liquid vehicle. Frequently, granules are used because the drug substance is unstable in aqueous environments and cannot be exposed to water for periods sufficient to accommodate manufacture, storage, and distribution in a suspension.

Which Dosage Form Is A Semisolid Oil-In-Water Emulsion Oil

Classically, an oleaginous vehicle such as a vegetable oil was used. A suitable quantity of hardening agents may be added to counteract the tendency of some drug substances (such as chloral hydrate and phenol) to soften the base. Factors to consider when choosing a. topical preparation: Match the type of preparation with the type of lesions. Additionally, dosage forms intended for the inhalation route of administration must be monitored for particle size and spray pattern (for a metered-dose inhaler or dry powder inhaler) and droplet size (for nasal sprays). Methods of preparation. Other orally administered pastes may be indicated for adhesion to the mucous membrane for a local effect. The surface-active properties of the vehicle facilitate contact of the drug substance with the skin or scalp.

Geometric dilution; ensures uniform mixing, use when small amounts of API are added to large amounts of base, mix equal amounts of base and API together. All other things being equal, the phase that is present in the greater concentration tends to be the external phase, but an emulsifying agent that strongly favors a particular emulsion type and that forms a good barrier at the interface can overcome an unfavorable phase ratio. These emulsifiers are the hard and soft soaps, which are discussed in Chapter 20, Surfactants and Emulsifying Agents. A suppository may have a local protectant or palliative effect, or may deliver a drug substance for systemic or local action. Absorption bases (cold cream, anhydrous lanolin, etc. These include droplet size, viscosity of the continuous phase, and relative density difference of the droplets and the continuous phase. They are designed for prolonged release (up to 7 days). Conversely, where water or an aqueous solution is the dispersed phase and oil or oleaginous material is the continuous phase, the system is designated as a water-in-oil emulsion. May cause irritation or allergy to some patients. A portion of the vehicle is used to wash the mixing equipment free of suspended material, and this portion is used to bring the suspension to final volume and ensure that the suspension contains the desired concentration of solid matter. Less irritating, while gels are irritating. This layer is spread uniformly on an appropriate support that is usually made of a rubber base or synthetic resin.

Because of the rapid dissolution, taste and mouth feel are important considerations. A spray may be composed of a pump, container, actuator, valve, nozzle, or mouthpiece in addition to the formulation containing the drug(s), solvent(s), and any excipient(s). Drug release also can occur as the matrix erodes. As described in Chapter 20, some emulsifiers will form either w/o or o/w emulsions; others form only one type. Ingredients needed for semisolid dosage form: - Bases. Does not want an irritating preparation to get onto the normal skin (e. g., anthralin paste. Tablet triturates: Small, usually cylindrical, molded or compacted tablets. If the medication is present as a suspension, the particle size must be controlled to promote uniform distribution of the drug substance and possibly optimize performance. If the propellant is in the external (continuous) phase, a quick-breaking foam is discharged. Creams can be water-in-oil or oil-in-water. ICH Guidance Q6A (available at) recommends specifications (list of tests, references to analytical procedures, and acceptance criteria) to ensure that drug products are safe and effective at the time of release and over their shelf life. Ability to reduce systemic metabolism. Solution: A clear, homogeneous liquid dosage form that contains one or more chemical substances dissolved in a solvent or mixture of mutually miscible solvents. Emollient: Attribute of a cream or ointment indicating an increase in the moisture content of the skin following application of bland, fatty, or oleaginous substances.

Viscous, low surface tension. 1) The calculated amount of acacia and all the oil contained in the formulation are put in a Wedgwood mortar and triturated until a smooth slurry results and all the acacia is properly wet by the oil. Although cocoa butter melts quickly at body temperature, it is immiscible with body fluids and this inhibits the diffusion of fat-soluble drug substances to the affected sites. Additional rules concerning the construction and use of cryogenic containers are promulgated by governmental agencies (e. g., U. S. Department of Commerce). Drug substances delivered in ointments are intended for local action or for systemic absorption. In the case of delayed-release formulations, the coating polymer is chosen to resist dissolution at the lower pH of the gastric environment but to dissolve in the higher pH intestinal environment. Lozenge: A solid dosage form intended to disintegrate or dissolve slowly in the mouth.

The mechanism for droplet generation and the intended use of the preparation distinguish various classes of sprays. Hypodermic tablets: Molded tablets made from completely and readily water-soluble ingredients; formerly intended for use in making preparations for hypodermic injection. The pill dosage form has been largely replaced by compressed tablets and by capsules.

We are sharing the answer for the NYT Mini Crossword of August 7 2022 for the clue that we published below. World War II, also called Second World War, conflict that involved virtually every part of the world during the years 1939–45. Leonie was also one of the main characters in Proust's "Remembrance of the Things Past". Source of protein for vegans NYT Crossword Clue. When you're selling shoes for hiking and aerobics, it's a different deal. What other categories have you sliced up? Like the characteristics of the flower after which she is named, Rose is a beautiful soul who protects her family and protects herself when Troy hurts her. We have a very focused category that has been built around the personalities of John McEnroe and Andre Agassi. They include: - Orion (the Hunter). Gussie: Gussie is one of the prettiest nicknames for Augusta. We're doing it because we think it's the right thing to do, but we also want the visibility. Like the figures for whom july and august are name index. Ara represents the altar on which the gods formed an alliance before going to war with the Titans in Greek mythology. When we did that, we came to see that focusing solely on the product was a great way for a brand to start, but it just wasn't enough.

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Each of those categories stands for something distinct. We went into casual shoes in the early 1980s when we saw that the running shoe business, which was about one-third of our revenues at the time, was slowing down. Here's how the early version would have looked. Scorpius is one of the Greek constellations, first catalogued by Ptolemy.

The constellation Phoenix represents the mythical firebird, sacred across many cultures and mythologies. The invasion began as ordered. Genitive: Microscopii. Genitive: Comae Berenices.

Like The Figures For Whom July And August Are Named One

Emotions are always hard to explain, but there's something inspirational about watching athletes push the limits of performance. Nike's roots go back to a company called Blue Ribbon Sports, which Knight, a former runner at the University of Oregon, and Bill Bowerman, Knight's former track coach, created in 1962. Equuleus constellation is usually associated with Hippe, the daughter of the centaur Chiron. Of or relating to or supporting Romanism. What if a Nike athlete does something illegal or socially unacceptable? The constellation was created in 1621 by Isaac Habrecht II, who originally named it Rhombus. The clue and answer(s) above was last seen in the NYT Mini. And you don't do casual shoes under that brand. Triangulum Australe means "the southern triangle" in Latin. Like the figures for whom july and august are namen mit. The war in the west, September 1939–June 1940.

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When Arcas grows up, he comes face to face with his mother in the woods and does not recognize her. Bill Bowerman, my former track coach at the University of Oregon and cofounder of the company that became Nike, had always customized off-the-shelf shoes for his runners. Later, the raven blames its tardiness on a water snake (represented by Hydra constellation), but the god is so angry that he casts all three – the raven, the water snake, and the cup (Crater) – into the sky. If you ever had problem with solutions or anything else, feel free to make us happy with your comments. But we got thousands of positive responses, and USA Today ranked it the best Super Bowl ad. Twelve constellations were created by Dutch explorers who sailed to Indonesia in 1595. Like The Figures For Whom July And August Are Named - Crossword Clue. The lessons we've learned about brand identity and focus can take us in many directions. Our engineers and designers spent a lot of time talking to the athletes about what they needed both functionally and aesthetically. Actually, we think of Cole-Haan as half a brand because only sophisticated consumers know what it is; it hasn't yet achieved critical mass. It is one of the six constellations associated with Perseus and was originally catalogued by Ptolemy in the 2nd century.

New York Times subscribers figured millions. Since Dutch explorers encountered many indigenous peoples on their expeditions, it is unclear if the constellation's name refers to a native of the East Indies, Madagascar, or South Africa. We wanted to communicate not just a radical departure in shoes but a revolution in the way Americans felt about fitness, exercise, and wellness. We bought the brand knowing its potential, and we've simply turned up the marketing volume. And from the beginning, we've tried to create an emotional tie with the consumer. Napoleon: Napoleon Bonaparte is one of the most prominent historical figures in France. Cetus constellation represents the sea monster sent by Poseidon to ravage King Cepheus' land after his wife Cassiopeia had boasted that she was more beautiful than the Nereids. It was named after the chameleon, a type of lizard that can change colour to match the environment. Even there it was risky to use such an intimate voice in the ads, but it worked. High-Performance Marketing: An Interview with Nike’s Phil Knight. Blue Ribbon Sports started out distributing running shoes for a Japanese company, then shifted to designing its own shoes and outsourcing them from Asia.

Like The Figures For Whom July And August Are Namen Mit

From the start, everybody understood that Nike was a running shoe company, and the brand stood for excellence in track and field. The constellation, created by Lacaille in the 17th century, was originally named le Chevalet et la Palette, or "the easel and palette, " and the name was later Latinized to Equuleus Pictoris, or "the painter's easel, " and eventually shortened to Pictor. If you want to know other clues answers for NYT Mini Crossword August 7 2022, click here. That should be all the information you need to solve for the crossword clue and fill in more of the grid you're working on! Hitler intended to invade Poland anyway, but first he had to neutralize the possibility that the Soviet Union would resist the invasion of its western neighbour. You can't create an emotional tie to a bad product because it's not honest. So did the NASCAR driver Jeff Gordon and his wife Kristin Olson. Despite great products and great ad campaigns, sales just stayed flat. In 24 words or less, that means innovative advertising—but innovative in a way that captures the athletes' true nature.

People already know a lot about him. That's where we're applying our marketing skill. Genitive: Capricorni. Boötes constellation is also sometimes associated with another mythical figure: Icarius, the wine maker. Apollo also casts a curse on the bird, turning its feathers black, and making the raven eternally thirsty. Which U. president signed the Marshall Plan into law? You can even go for Camryn as it is a more feminine spelling. For instance, Friday, Troy's payday, is the setting of three scenes. Auriga – The Charioteer.