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Simultaneous HPLC Determination of Content of Catalpol and Verbascoside in Rehmannia. Activates Blood, dispels Blood Stasis, clears Heat and alleviates pain. Chinese herbal medicines that have the effect of moving Qi and activating the blood will also be prohibited. Degree of each node can be used to evaluate the importance of nodes in the network. The PPI data was extracted from seven published database, include STRING [13], BioGRID, HPRD, Dip, Intact, Reactome and Mint. This product is not intended to diagnose, treat, cure or prevent any disease. Uncovering the potential mechanism of Xue Fu Zhu Yu Decoction in the treatment of intracerebral hemorrhage | BMC Complementary Medicine and Therapies | Full Text. The compounds with Caco-2 > -0. The results showed that the coverage rates of the three enriched pathways were 87. Diels are usually used to nourish blood and nourish yin, clear heat and promote blood circulation; Platycodon grandiflorus (Jacq. ) Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used prescriptions in treating ICH at clinic level, has not been clear about its mechanism.

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Draghici S, Khatri P, Tarca AL, Amin K, Done A, Voichita C, Georgescu C, Romero R. A systems biology approach for pathway level analysis. Other potential uses with the correct underly…. Showed that early treatment with the best dose of quercetin could improve the brain injury after intracerebral hemorrhage model by inhibiting inflammatory reaction and reducing apoptosis [39], thus promoting the recovery of neural function. The results show that the CCG with 43 compounds predicted by this model is highly consistent with the corresponding Compound-Target (C-T) network in terms of gene coverage, enriched pathway coverage and accumulated contribution of key nodes at 89. Xue Fu Zhu Yu Wan may potentially be used, in coordination with a well tailored overall approach, to influence the following conditions: dizziness (vertigo), dysmenorrhea (menstrual pain - cramps), headache, heart disease, hepatitis (b or c), hiccups, hypertension (high blood pressure), insomnia and/or irregular menstruation. Xue Fu Zhu Yu Tang- 血府逐瘀湯- Drive Out Stasis In The Mansion Of Blood Decoction. Members are generally not permitted to list, buy, or sell items that originate from sanctioned areas. IBRCM: China Academy of Chinese Medical Sciences. The repeated measure analysis of variance will be conducted to distinguish the treatment effect and time effects. This network is consisting 2, 932 nodes and 48, 980 edges.

Discontinuing interventions. Qian, H., Liu, L. J., Li, Y. C., Xie, M., Wu, H., Liu, S. X., & Wu, B. Simultaneous Determination of Glycyrrhizin, Liquiritin and Isoliquritigenin in Licorice by HPLC. Dark or purplish lips, conjunctiva or nail beds. Irregular menstruation. Nourishes and invigorates Blood.

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2011) determination of 3 compounds of triterpenoid saponins in Platycodon grandiflorum. Weighted pathogenic gene–gene interaction network plays an important role in disease occurrence, drug response and other life activities. The analysis will be based on the intent-to-treat (ITT) and the per-protocol (PP) principle. Wang, F., Lu, D., Liu, C., Chen, X. H., Bi, K. S., & Li, Q. Xue fu zhu yu wan equilibrium. With Chuan Xiong, harmonizes, nourishes and invigorates the Blood, disperses Blood Stasis and treats abdominal pain. Both XFZY and the placebo will be labeled and packaged based on a randomization sequence by Jilin Aodong Yanbian Pharmaceutical Co. under the supervision of IBRCM. Hu YJ, Pu JB, Liang WQ, Zheng JX, Wei KM. Xu X, Wang W, Xi W, et al.

We treated the first three columns as upstream locations of the integrated pathway, and the remaining columns as downstream locations of the integrated pathway. Participants will self-rate their peak pain intensity using VAS, report menstrual pain duration, and fill out CMSS at baseline and each visit. Sanctions Policy - Our House Rules. 7), the PI3K-Akt signaling pathway and the MAPK signaling pathway. AE details include the time of occurrence, severity, causality to the intervention, whether the event was serious, action taken, and AE outcome. Please call Oregon branch at. Myocardial infarction. Used systematic pharmacology to analyze the synergistic mechanism of LiuWei DiHuang Pill in Type 2 Diabetes Mellitus [12].

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Interested PD patients can register for this trial by contacting researchers. Liu H, Zeng L, Yang K, Zhang G. A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility. 2 (SAS Institute Inc., Cary, USA) and performed by the Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences (IBRCM). Li, G., Zhang, Z., Zhou, L. et al. Showed that 5-lipoxygenase (5-LO) activator protein (FLAP) was encoded and synthesized by ALOX5AP gene, which was necessary for 5-LO activation and leukotriene synthesis [42]. Formulas may be used alone, in combinations, and/or in stages. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Xue fu zhu yu wan ying. With Tao Ren, Hong Hua, Dang Gui and Chai Hu, for sharp stabbing pain in the chest and hypochondriac area due to Blood Stagnation. For example, PI3K-Akt signaling pathway (hsa04151) has been reported to be involved in the inhibition of apoptosis, cell proliferation, and expression of inflammatory cytokines.

System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of Zhi-zhu Wan for Functional Dyspepsia. China Health Care Nutr. Heart Blood Stagnation. The protocol version is V1. Ear Magnets and Seeds. Chinese J Inform TCM. Meet the diagnostic criteria for PD and QBP in CM. BMC Complementary Medicine and Therapies volume 22, Article number: 103 (2022).

BF2019-175-01) and each center. After 24 h of incubation, 10 μL of CCK8 was added and incubated for a further 4 h. The plate reader was utilized to detect the absorbance at 450 nm. XFZY's components include Persicae semen (Taoren), Carthami flos (Honghua), Rehmanniae radix (Dihuang), Angelicae sinensis radix (Danggui), Chuanxiong rhizome (Chuanxiong), Paeoniaeradix rubra (Chishao), Achyranthis bidentatae radix (Niuxi), Platycodonis radix (Jiegeng), Bupleuri radix (Chaihu), Aurantii fructus (Zhiqiao) fried with bran, and Glycyrrhizae radix et rhizome (Gancao). The placebo will be identical to the XFZY in appearance, weight, taste, smell, and packaging. These results proved the important role of these compounds in treating ICH, and further confirmed the multi-compounds role of XFZYD in ICH treatment. Blood Stasisclear has a mild action and therefore it usually takes time before its effects become apparent. Xue fu zhu yu wan yi. VEGF signaling pathway (hsa04370) is very important for cell proliferation and growth. Cotton & Paper Products. Cochrane handbook for systematic reviews of interventions version 5. Herbal Times® Supplements are Laboratory Tested to insure the the highest. 202002030221), the Natural Science Foundation Council of China [grant No. Biochem Biophys Res Commun. To remedies that focus on modern concerns such as blood sugar and stress. Ethics approval and consent to participate.

The pharmacopoeia of the People's Republic of China 2015 edition. Gao Y, Wang KX, Wang P, Li X, Chen JJ, Zhou BY, Tian JS, Guan DG, Qin XM, Lu AP. With Tao Ren, Hong Hua and Chuan Xiong, for Blood Stagnation in the chest.

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